The FDA says esketamine, an antidepressant derived from the anesthetic and party drug ketamine, can now be prescribed on its own. It was approved in 2019 to treat severe depression.

In zebrafish, ketamine causes changes a brain circuit involved in "giving up." That may help explain how the drug helps people with depression.

Psychedelic drugs were a hot topic at this year's Society for Neuroscience meeting. Researchers hope the drugs can help people with disorders like depression and PTSD.

Scientists have made a drug based on LSD that seems to fight depression without producing a psychedelic experience.

Ketamine, a Schedule III non-narcotic substance, has been available to licensed prescribers since the 1970s. Since then, multiple studies have shown ketamine helps some depression patients who feel as though they’ve tried everything else. 

The remedy is a new type of transcranial magnetic stimulation that's showing good results in just five days of treatment. For some patients, it's life-changing.