Fentanyl fueled unprecedented carnage with 112,000 fatal overdoses. The nation is increasingly divided over how to respond.

The federal government made naloxone nasal spray available over the counter this year, and that availability is helping naloxone become a life-saving measure in shelters, jails and schools.

The majority of drugs tested after an opioid overdose — 90% — contain fentanyl, which is a synthetic opioid that is up to 50 times stronger than heroin and 100 times stronger than morphine. That's why some health experts are calling for nasal nalmefene to be available over the counter.

Renae was so desperate to keep her child alive when so many others have died from overdose that she resorted to extreme measures — and extreme risks. She now supervises drug use in her own home.

Louise Vincent has used drugs since she was 13. Research shows millions of Americans like her aren't ready or able to stop. Vincent believes it's time people accept that.

Threatening letters sent to local election offices in at least five states, some including fentanyl, are the latest concern for local election workers around the country. They already have faced harassment and even death threats since the 2020 presidential election.

The letters were sent to elections offices in the presidential battlegrounds of Georgia and Nevada, as well as California, Oregon and Washington, with some being intercepted before they arrived.

Fulton County elections officials are preparing after federal officials warned that a letter possibly containing fentanyl is in transit to the elections office.

Cloud, 25, who starred as a drug dealer on the HBO series, died of "acute intoxication," a California coroner's office said. His family has said he'd been struggling with the death of his father.

The operator of a Bronx day care and a relative are facing drug charges after a 1-year-old boy died and three other children became dangerously ill.

Ovidio Guzmán López, a son of Joaquin "El Chapo" Guzmán, faces drug trafficking, money laundering and other charges in the United States. Mexican security forces captured Guzmán López in January.

A new study finds a 50-fold growth in deaths from combined use of stimulants and opioids. The toxic and contaminated drug supply is to blame.

The share of overdose deaths involving counterfeit pills doubled between 2019 and 2021, according to the CDC. Victims were often younger, Hispanic and had misused prescription drugs in the past.

The fentanyl-additive Xylazine causes open wounds, making the illegal drug supply even more dangerous and treatment more complicated

We know that illicit fentanyl is flowing into the U.S. from Mexico. Yet we rarely hear from the couriers who smuggle most of it through legal ports of entry. This is one of their stories.