President Biden called the killing of Hassan Nasrallah "a measure of justice for his many victims," while Iran's supreme leader condemned what he called an Israeli massacre in Lebanon.

Under his leadership, Hezbollah, funded by Iran, became one of the most powerful militias in the Middle East, boasting a military force stronger even than the Lebanese army.

With Hassan Nasrallah dead in Israeli airstrikes, the Iran-backed militant group is facing enormous challenges as the region is yet again thrown into uncertainty.

The militant group confirmed the death of its longtime leader Hassan Nasrallah in Beirut. The development marks a significant escalation many fear is inching towards a larger regional war.

Hezbollah leader Hassan Nasrallah was said to be the target of the strikes, but it was not immediately clear if he was at the site when they happened.

The Israeli military said it carried out an airstrike on the headquarters of Hezbollah in Beirut, shortly after Israeli Prime Minister Benjamin Netanyahu addressed the United Nations.

In a fiery speech at the United Nations General Assembly, the Israeli prime minister said his country would is "winning" and would attack Iran and its proxies anywhere in the Middle East.

With Israel and Hezbollah locked in the fiercest fighting in decades, many Lebanese have taken refuge in schools, hotels and other shelters.

The U.S., France and other allies jointly called Wednesday for an immediate 21-day cease-fire to allow for negotiations in the escalating conflict between Israel and Hezbollah.

For Palestinians in the Israeli-occupied West Bank, access to water has been a struggle for years. But since last Oct. 7, water has become even harder for them to obtain.

Hezbollah launched a ballistic missile at Tel Aviv early Wednesday, after Israel carried out strikes on Lebanon that killed hundreds of people and the militants fired rockets across northern Israel.

The trade of cross-border missiles came after the deadliest day of conflict in Lebanon since 2006. Lebanon’s health ministry said on Tuesday that 558 people have been killed.

Fighting is escalated at the Israeli-Lebanese border in one of the deadliest days of nearly a year of conflict in the region.

Russia and Ukraine have fought for a decade. The Israel-Hamas war is part of a conflict dating back generations. NPR’s Greg Myre has covered both wars, and looks at why they seem to defy a solution.

The Israeli military on Monday called on people in southern Lebanon to immediately evacuate homes and other buildings where Hezbollah stores weapons and said it was carrying out "extensive strikes."