Extensive damage to buildings, homes and infrastructure can be seen across the area as the tornado moved from the southwest to the northeast directly through the town, the technology firm Maxar said.
The international atomic watchdog has been to some of the world's toughest locations, but nothing quite like Europe's largest nuclear power plant in an active war zone.
Satellite images and social media analyzed by NPR show attacks have hit structures around the plant, coming dangerously close to causing a nuclear disaster.
The massive explosion leveled the city's port and scattered debris across a road thousands of feet away. The blast killed at least 100 people and injured thousands more.