An effective treatment for opioid addiction is easier to get after the Biden administration changed rules. That's making a difference for some people battling opioid use disorder, but access is still limited.

For decades, tianeptine was used to treat depression, even though no one knew how it worked. But it turns out it's a type of opioid, and the U.S. is facing a spike in abuse of "gas station heroin."

A new study finds a 50-fold growth in deaths from combined use of stimulants and opioids. The toxic and contaminated drug supply is to blame.

New research calls into question prescribing the drugs even for short-term pain relief – especially given the risk of addiction.

Republican lawmakers want Mexico to accept U.S. military aid to cripple drug cartels making and smuggling deadly fentanyl. López Obrador mocked the idea as a threat to his country's sovereignty.

Federal prosecutors in Southeast Georgia announced Wednesday a massive drug trafficking indictment, charging 76 people — including a state prison guard — with operating a drug distribution network of opioids and other controlled substances in and around Brunswick's Glynn County.

The retail giant becomes the latest major player in the drug industry to announce a plan to settle lawsuits filed by state and local governments over the toll of opioids sold at its pharmacies.

The updated recommendations seek to course correct after guidelines from 2016 were criticized for harshly limiting access to needed pain medication.

Many blame the agency's earlier guidance for suffering and even suicide risk among chronic pain patients. Critics say the updated advice may not fix the problem.

Companies at the center of the deadly prescription opioid epidemic are close to deals that would cap their liability while funding drug treatment and recovery programs.

The country's biggest name-brand pharmacy chains face a high-profile civil trial beginning Monday in Cleveland, Ohio over their role in the nation's deadly opioid epidemic.

Cherokee Nation officials say their community has been disproportionately harmed by the opioid crisis. The drug companies deny any wrongdoing.

People who were addicted to OxyContin or lost loved ones who were addicted to the drug expect very little in compensation from the multibillion-dollar Purdue Pharma bankruptcy settlement.

Newly published U.S. data finds overdose deaths from methamphetamine use more than doubled in recent years. Use of the stimulant among Black Americans surged nearly tenfold.

The DOJ is seeking to block implementation of any part of the Purdue Pharma bankruptcy deal until legal challenges are settled. The deal granted Sackler family members immunity from opioid lawsuits.