The rocket cleared the launchpad and separated from its booster, surpassing the first attempt. But minutes later, controllers lost contact with the vehicle.
A portion of the trailblazing actor's ashes will travel to deep space later this year. Along for the journey are remains of the show's creator and another star from the series.
NASA's Artemis 1 rocket, the Space Launch System, reached the Kennedy Space Center's Launch Complex 39B on Friday. The successor to the Apollo program could one day send humans back to the moon.
Watkins will join the fourth SpaceX Crew next April on her way to entering the ranks of other history-making women at NASA like astronauts Mae Jemison and Sally Ride.
Marking the latest step in the commercialization of space, the SpaceX mission set to launch Wednesday will carry four civilians, including a billionaire CEO, a physician assistant and a geoscientist.